Hodgkin Disease
Hodgkin Disease 內容預覽：
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Hodgkin Disease 內容簡(jiǎn)介：
HodgkinDisease
Definition:
neoplasticdisorderwithdevelopmentofspecificinfiltratecontainingpathologicReed-Sternbergcells.Itusuallyarisesinlymphnodesandspreadstocontiguousgroups.Extranodalpresentationarerare.Diseaseisassociatedwithdefectivecellularimmunity.
HodgkinDisease
Incidence:
-2-4casesper100000population/year
-bimodalagedistribution:
15-35yearsandabove50years
-malepredominanceM:F=1,7:1
ClinicalPresentation
Nontenderlymphnodesenlargement(localised)
neckandsupraclaviculararea60-80%
mediastinaladenopathy50%
other(abdominal,extranodaldisease)
systemicsymptoms(Bsymptoms)30%
fever
nightsweats
unexplainedweightloss(10%per6months)
othersymptoms
fatigue,weakness,pruritus
cough,chestpain,shortnessofbreath,venacavasyndrome
abdominalpain,boweldisturbances,ascites
bonepain
DiagnosisofHodgkinDisease
isbasedonmicroscopicexaminationoflymphnodeorotherinvolvedtissue
itrequiresidentificationofdiagnosticReed-Sternbergcells
PathologicClassification
WHO
ClassicalHodgkindisease
lymphocyterich(LR)
nodularsclerosis1and2(NS)
mixedcellularity(MC)
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